If I correctly understand this passage, and if it’s true, we were alienated from God and an enemy of his before receiving faith in Christ. The same must also be true of our friends who aren’t Christians, but their built-in enmity is not something to lose any sleep over.
Remember Saul on the road to Damascus? He hated Christians, and was personally persecuting Jesus. Yet in a moment, the unlimited power of God changed him into a willing servant, and committed follower of his former enemy. That same power is available to change the heart of your friend or loved one who is seemingly lost without hope.